Dr. Michael McNamara, M.D., Diagnostic radiologist, Monte-Carlo
LifeCheck (R) The Principality of Monaco and Dr. Franco Coce, Prim
Dr. med specialist internist & diabetologist, Zagreb, Croatia
HEALS WOUNDS BETTER AND UP TO TWICE AS FAST, REDUCES PAIN, DISCOMFORT
wound healing effects of BIOPTRON light therapy is undoubtedly associated
with improvement of blood microcirculation, enhancement of the trophic
function of blood, but also with increase of concentration in blood
serum of growth factors and some cytokines" - Professor Samoilova,
PhD, DSci, Prof International leader in Photobiology and Photomedicine.
the area of wound healing, BIOPTRON Light Therapy can be used as
a stand alone therapy and / or as a complementary - additional therapy
for the treatment of:
Wounds after injury (post traumatic wounds)
Post operative surgical wounds
Pressure Sores (Decubitus)
Leg Ulcers (Ulcus Curis)
wound healing is a complex process consisting of different stages
which are divided into three overlapping phases:
Proliferation (granulation tissue formation)
process of wound healing requires the interaction of cells in the
dermis (lower part of the skin) and epidermis (upper part of the
skin) as well as the activity of chemical mediators (biochemical
substances responsible for biological activities in the human body)
released form inflammatory cells, fibroblasts and keratinocytes
(specific cells playing a part in would healing).
BIOPTRON Light treatment can promote and speed up wound healing
and lead to rapid regeneration of epithelium (skin tissues) in the
edges and depth of a wound.
Significantly reduced healing period
Medically proven effectiveness
Unique successes, confirmed clinical studies
ULCERS (VENOUS LEG ULCERS)
wounds are underestimated by physicians and general public alike,
yet their prevalence continues to increase dramatically because
of the steady growth of the elderly population and because the elderly
at an increased risk in respect to chronic wounds.
need to care for the population with chronic wounds is a growing
challenge that requires innovative approaches.
believe that the use of BIOPTRON Light Therapy and in conjunction
with existing procedures could greatly enhance the natural wound-healing
process. Furthermore, improved wound healing could reduce the risk
of infection for the patient, decrease the number of costly dressings
required, and more importantly return the patient to a pre-injury/illness
level of activity.
Light Therapy Systems provide new insight into the management of
venous leg ulcers, pressure ulcers, diabetic foot ulcers, burns,
grafting and wounds following operation and injury. Patients are
now able to receive innovative wound-care management. BIOPTRON Light
Therapy could offer significant support in conjunction with standard
healing has a highly complex set of physiological processes regulated
by many different cellular and humoral factors
complex process of wound healing can be influenced by BIOPTRON Light
spite of the positive clinical experiences reported in numerous
publications, the mechanism of the biological effect of polarized
light is still under investigation. It is assumed that, in the cell
membranes, the polar heads of the lipid bilayer are reordered by
polarized light and that, as a consequence, functional changes take
biological effects have been observed after light therapy, including
the stimulation of cell proliferation - especially fibroblasts,
the release of growth factors and the enhancement of collagen synthesis.
(3,4,5). A number of clinical studies have revealed accelerated
wound closure with increased wound epithelization and improved tensile
strength of scars. (4-7)
proposed mechanism of action of photostimulation is the absorption
of visible light by mitochondria. (8) This may cause a chain of
reactions on a molecular level, leading to an increase in cell energy
and activation of the nucleic acid synthesis, which is essential
in wound repair. The second proposed mechanism is related to the
infrared portion of the light spectrum. This initiates the response
at the membrane level, probably through photophysical effects on
Ca++ channels (9). Light therapy has been shown to stimulate release
of the growth factors from the irradiated cells. Growth factors
stimulate angiogenesis, extracellular matrix production and degradation
of cytokine release (10). The key cells in skin ulcer contraction
and collagen synthesis are fibroblasts and keratinocytes. A number
of studies have demonstrated their activation and proliferation
in response to low-energy laser/photon stimulation.
mechanism that may be responsible for the light's therapeutic effect
is the local peripheral vasodilatation, which may enhance skin blood
flow and supply of oxygen to the ulcerated area, thereby facilitating
the transportation of the nutrients required for healing (10).
leg ulcer is defined as a wound on the leg, below the knee that
fails to heal within a 6 week period. Venous leg ulcers constitute
the majority of all leg ulcers and are responsible for up to 80%
of lower extremity ulceration's. An overall prevalence of venous
leg ulcers ranges from 0.06% to 2.2% with a tendency to increase
as the population ages.
prevalence of venous leg ulcers in patients after 70 years of age
is estimated to be 1 to 4%.
leg ulcer refers to a failure of the venous system to return blood
to the heart. This is usually caused by incompetent valves in the
deep veins, the long saphenous vein, the short sphenous vein or
the perforator veins of the calf which are situated in the leg.
to the weak venous valves blood from the deep veins in the legs
flows back into the minor veins (called the superficial veins) whereas
the traffic should only be one way. This lads to a build up of blood
in the superficial veins which will slow down and many eventually
stop flowing. This may result in a metabolic breakdown particularly
in the surrounding skin area and the skin may start to degenerate
giving rise to inflammation and ultimately the development of an
leg ulcers are difficult to heal and their complete healing may
take years. Many patients with leg ulcers suffer from pain resulting
in problems along with both sleep and mobility resulting in severe
impairment in quality of life.
positive effect of BIOPTRON Light Therapy on the cells composing
tissue in the leg region has been shown to enhance the healing process
in patients with venous leg ulcers. BIOPTRON Light applied as a
stand alone therapy has been shown to result in complete wound healing
and or it can be considered effective in the treatment of venous
leg ulcers when used as an integral part of a wound management programme.
is widely known that light therapy can accelerate the healing of
wounds and superficial skin ulcers (1,2) The favourable effect of
BIOPTRON Light Therapy on the healing rate of venous leg ulcers
may be explained by the stimulation of epithelial growth and granular
tissue regeneration (10)
photographs Source: Institute of Dermatovenerology, Department of
Dermatovenerology, Belgrade University , School of Medicine , Belgrade,
Serbia and Montenegro.
assessment: Measurements of wound surface area (ulcer size) by computerised
planimetry Planix Digital Panimeter)
(10) Medenica, L, Lens, M. The use of polarised polychromatic non-coherent
light alone as a therapy for venous leg ulceration. Journal of Wound
Care 2003; 12: 1. 37-40
second degree burns
Fig 1: Single case (Source: Department of Plastic Surgery, University
Hospital Gent, Belgium) showing the effect of BIOPTRON Light Therapy.
2: Monstrey, S,, Hoeksema,, H., Salens, H, Depuydt, K., Hamdi, M.,
Van Landuyt, K., Blondeel, P.A. A conservative approach for deep
dermal burn wounds using polarised-light therapy. British Journal
of Plastic Surgery 2002; 55; 420-426
and superficial second-degree burns may be treated with conservative
local medical treatments in combination with BIOPTRON Light Therapy
treatment. Clinical studies have shown that the routine use of BIOPTRON
Light Therapy may significantly reduce the time necessary for complete
epithelization of the damaged skin, reducing the risk for the formation
of the functionally and esthetically unacceptable scars (11)
Second Degree Burns
Light Therapy has been used in the treatment of burns for many years
and the treatment of burns depends on the depth and severity of
the injury. A standard classification results in precise treatment
such as conservative or surgical intervention.
Degree Burns are the mildest form
good example is sunburn. First degree burns are normally characterized
by reddening of the skin, slight swelling and pain and discomfort.
The symptoms normally disappear within a few days without leaving
Degree Burns are
called partial thickness burns and are divided into superficial
and deep burns.
the superficial second degree burn the entire epidermis (upper part
of the skin) and a superficial part of the dermis (the lower part
of the skin) are destroyed.
the depth of the burn is relatively superficial there are usually
no long term effects to the skin hair follicles, sweat glands or
nerve endings. Usually the damaged skin regenerates with two weeks
after the injury.
Second Degree Burns are more serious.
is generally damage to the deep layer of the dermis with only a
few hair follicles, sweat glands and nerve endings remaining at
the base of the wound. These wounds require surgical removal of
dead tissue and transplantation of skin - skin grafting. More than
50% of burns are deep second degree burns or full dermal burn wounds.
Degree burns (full thickness burns) are where all of the layers
of the skin are destroyed leaving no possibility for the injury
to heal naturally unless the burn covers a very small area and require
surgery. The major complications of such wounds are infection, development
of scars and contractures.
FOR FIRST DEGREE AN SUPERFICIAL SECOND DEGREE BURNS
burns can be treated with conservative local medical treatment approaches
in combination with BIOPTRON Light Therapy. Several studies have
shown that the routine use of BIOPTRON Light Therapy can significantly
reduce the time necessary for complete epithlisation (regeneration
of the skin) towards complete healing thereby effectively reducing
the formation of scaring.
findings show how the application of pressure therapy can start
earlier if the burn area has been treated with BIOPTRON Light Therapy.
In addition if the body area (save for the hands) are treated with
BIOPTRON Light Therapy then physiotherapy can begin immediately.
Light Therapy has been used to treat patients with deep second degree
burns after surgical procedures have been carried out to reduce
healing time and time in hospital.
- pressures sores commonly referred to as a bedsore
and this form of pressure ulcer is caused by prolonged pressure
on specific body areas in patients confined either to bed or wheelchair.
They tend to develop on an area of the body where bony prominence
is not protected by muscle tissue such as the sacrum (the tailbone
at the base of the spine), heels, elbows and shoulder blades. When
the pressure cuts off the blood supply cells and tissues composing
the skin are damaged and ulcers start to form creating a potential
breeding ground for harmful bacteria with increasing infection.
in ten hospital patients, one in eight home care patients and one
in four nursing home patients suffer from bedsores. The problem
is seen to be growing due to the ageing population and in every
hospital the number of patients requiring treatment for bedsores
is increasing creating high levels of demand on resources and funding.
involves taking pressure off of the body area requiring high levels
of nursing and healthcare provision. The pressure ulcers are cleaned
although in some cases the use of surgical intervention is required.
BIOPTRON Light Therapy has been shown to be an effective therapy
to accelerate tissue healing and repair.
studies have demonstrated the effectiveness of polarized light therapy
in healing 1st, 2nd and 3rd grade pressure ulcers. When polarized
light treatment was added to conventional ulcer therapy, rapid changes
in appearance and size with complete healing in half of the cases
and accelerated partial healing in the remaining cases appeared
within 1-2 weeks (13)
images Source Single case Department of Plastic Surgery, University
Hospital Gent, Belgium. Showing the effect of BIOPTRON Light Therapy.
Light Therapy also play an effective role in the prevention of bedsores.
Light Therapy has been used to treat diabetic foot ulcers and clinical
results have confirmed its positive influence on the affected and
treated areas. The ulcers gradually cleared, granulated and epithelized
during treatment. Healing time was substantially shortened and ulcer
pain was lower compared to treatment without BIOPTRON light therapy
Light Therapy is a very simply and effective additional therapy
in treatment of surgical wounds.
19. Simic, A.,
Peskin, P., Bjelovic, M., Stojakov, D., Todorovic, M., Jekic, I.,
M icev, M., Sabljak,P., Kontarak, M., Bioptron Light Therapy and
Thoracoprenolaprotomy wound healing in patients operated due to
cardiac carcinoma. Presented at the 4th International Gastric Congress,
New York, USA. April 30 -May, 2001
frequently encountered in the elderly and those who are bedridden.
Typical characteristics of chronic wounds include a loss of skin
or underlying tissue and failure to heal with conventional types
wounds are difficult to heal and require a long time to complete
closure. The relative resistance of chronic wounds to a wide range
of therapeutic approaches and the absence of a standard single therapy
for the treatment of chronic wounds shifted the attention of many
researchers towards the investigation of other therapeutic approaches.
use of different sources of light therapy in wound healing therapy
has gained particular attention in the last few decades, and many
clinical studies have evaluated the role of light therapy in the
management of wounds.
Light Therapy can promote and speed up wound healing through the
stimulation and modulation of reparative and regenerative processes,
anti-inflammatory effects and enhancing processes of the human defense
system. This type of phototherapy can be considered a valuable therapy
in the treatment of various wounds and would healing disorders.